Issue 7 - February 2012
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1) Reference Material
2) Biomarker Beacon
3) Metabolomics Current Contents
|29 Feb 2012
Mitochondrial Dysfunction Present Early in Alzheimer's, Before Memory Loss - Mitochondria — subunits inside cells that produce energy — have long been thought to play a role in Alzheimer's disease. Now Mayo Clinic researchers using genetic mouse models have discovered that mitochondria in the brain are dysfunctional early in the disease. The findings appear in the journal PLoS ONE.
The group looked at mitochondria in three mouse models, each using a different gene shown to cause familial, or early-onset, Alzheimer's disease. The specific mitochondria changes corresponded with the mutation type and included altered mitochondrial movement, structure, and energy dynamics. The changes happened in the brain even before the mice showed any symptoms such as memory loss. The group also found that the mitochondrial changes contributed to the later loss of mitochondrial function and the onset and progression of Alzheimer's disease.
"One of the most significant findings of this study is our discovery of the impact of mitochondrial dysfunction in Alzheimer's disease," says Eugenia Trushina, Ph.D., Mayo Clinic pharmacologist and senior investigator on the study. "We are asking: Can we connect the degree of mitochondrial dysfunction with the progression of symptoms in Alzheimer's disease?"
Enlisting the expertise of Mayo researcher Petras Dzeja, Ph.D., the team applied a relatively new method called metabolomics, which measures the chemical fingerprints of metabolic pathways in the cell — sugars, lipids, nucleotides, amino acids and fatty acids, for example. It assesses what is happening in the body at a given time and at a fine level of detail, giving scientists insight into the cellular processes that underlie a disease. In this case, the metabolomic profiles showed changes in metabolites related to mitochondrial function and energy metabolism, further confirming that altered mitochondrial energetics is at the root of the disease process.
The researchers hope that the panel of metabolomic biomarkers they discovered can eventually be used for early diagnosis, treatment, and monitoring of Alzheimer's progression.
"We expect to validate metabolomic changes in humans with Alzheimer's disease and to use these biomarkers to diagnose the disease before symptoms appear — which is the ideal time to start treatment," Dr. Trushina says.
Paper: Trushina E, Nemutlu E, Zhang S, Christensen T, Camp J, et al. (2012) Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease. PLoS ONE 7(2): e32737. doi:10.1371/journal.pone.0032737 (PLoS ONE).
Source: Mayo Clinic
|29 Feb 2012
Metabolon Publishes Book Chapter Describing Its Analytical Software - Metabolon, Inc., a diagnostics and services company offering the industry’s leading biochemical profiling technology, announces the publication of "Software Techniques for Enabling High-Throughput Analysis of Metabolomic Datasets" in the book Metabolomics, ISBN 978-953-51-0046, edited by Ute Roessner and published by the open-access publisher, InTech. The book chapter describes software and computational tools developed by Metabolon to quickly and accurately process, analyze and interpret metabolomics data in a high-throughput environment.
The use of metabolomics to answer a variety of biological questions has increased dramatically over the last few years. Metabolomics analysis requires accurate and sensitive instrumentation (LC/MS, GC/MS, NMR, CE, etc.) to generate high-quality data that can be easily and rapidly analyzed. While instrumentation holds a critical role, processing the massive amounts of data generated by a metabolomics experiment is a major rate-limiting step. Metabolon has developed a suite of software and computational tools that play an important and direct role in the ability to process, analyze, and interpret metabolomics data. Through the implementation of these techniques the biochemicals in an experimental sample can be quickly and accurately identified which enables biochemical interpretation of the results and facilitates the understanding of biological mechanisms and modes of action.
Book Chapter: http://www.intechopen.com/articles/show/title/software-techniques-for-enabling-high-throughput-analysis-on-metabolomic-datasets
Source: Metabolon Press Release
|21 Feb 2012
Kitware Launches Visomics, an Open-Source Bioinformatics Application
The open-source, omics-specific tool aims to accelerate the pace of research through definition of relationships between biological analytes and biomarkers.
Kitware, one of the nation’s fastest-growing technology companies, today introduces "Visomics," an all-encompassing open-source application for performing biological research pertaining to genomics, protemomics, transcriptomics and metabolomics.
The application is built on top of Kitware's powerful open-source toolkits and is easily configured to support underlying 'omics applications, which can be customized to meet the particular needs of researchers. Currently in alpha/beta mode, Visomics provides the statistical methods, intuitive visualizations, and pre-existing chemical pathway diagrams that biologists need for the tracking, storage, analysis and evaluation of relationships and behaviors of large numbers of analytes and biomarkers.
Clinical researchers are using Visomics to delve deep into the areas of reproductive and perinatal health, cardiovascular disorders and breast cancer. By leveraging Visomics, researchers are seeking out new insight into disease pathogenesis and developing preventative, diagnostic and therapeutic treatment strategies.
"We are excited to see how Visomics impacts the field of biological research," said Wesley Turner, Ph.D and Principal Investigator. "With Visomics, workflows can be streamlined allowing researchers to focus on the data and make new discoveries."
Visomics is designed to be user-friendly for use by bioinformatics experts and non-experts alike. By facilitating data analysis and mining activities for a wide range of users, Visomics will enable more widespread use of ‘omics data and ultimately lead to quality personalized medicine.
Supported by SBIR Phase I funding from the National Institute of Health, Visomics is developed and maintained by Kitware Inc., the Hamner Institute for Health Sciences, the University of Washington, and the University of North Carolina at Chapel Hill.
For more information regarding Visomics and how you can incorporate it into your bioinformatics workflow, please visit http://www.visomics.org.
|12-14 Mar 2012||
Metabolic Leaders' Forum 2012
Phacilitate’s inaugural Metabolic Leaders’ Forum
takes a timely look at the decisions facing senior
R&D executives following the tightening up of
requirements for approving new drugs for adult-onset
diabetes coupled with the FDA’s more recent rejection
of three separate drugs to treat obesity. What are
your peers doing to establish appropriate CV benefits
profiles to demonstrate positive outcomes without
incurring exploding costs? How are companies large and
small rethinking and restructuring to optimize their
ability to compete in diabetes and obesity, and the
emerging cardiometabolic health field?
|17-20 Apr 2012||
analytica Conference 2012
In various symposiums, leading scientists from all over the world report on the latest developments, current trends and visions of the future. Analytic, diagnostic, biochemical and molecular biological methods and procedures are discussed here. On the last occasion, 140 well-known experts gave talks in 23 different thematic symposiums.
Main subject emphases/highlights of the analytica Conference 2010
For more information, please visit http://www.analytica.de/en/Home/congress/conference-program.
|7-8 May 2012||
LIPID MAPS Annual Meeting 2012: Lipidomics
Impact on Cell Biology, Metabolomics and
The meeting program tentatively features the following six sessions:
For more information, please visit http://www.lipidmaps.org/meetings/2012annual/
|20-24 May 2012||
60th ASMS Conference on Mass Spectrometry and
Jan 9, 2012: Conference registration and lodging opens online
Feb 3, 2012: Deadline for submission of abstracts
Apr 14, 2012: Conference program online
Apr 30, 2012: Deadline for advance registration
For more information, please visit http://www.asms.org/Conferences/AnnualConference/GeneralInformation/tabid/127/Default.aspx.
|21-23 May 2012||
Les 6èmes Journées
Scientifiques du Réseau Français de
Métabolomique et Fluxomique (JS 6 RFMF)
For more information, please visit https://colloque4.inra.fr/6_js_reseau_francais_metabolomique_fluxomique.
|25-28 June 2012||
METABOLOMICS 2012: Breakthroughs in plant,
microbial and human biology, clinical and
nutritional research, and biomarker discovery
The 2012 meeting promises a program full of practical workshops and parallel sessions covering the broad range of biological and technological metabolomics topics as well as providing rich opportunities for networking. Join us as we gather together to share ideas, insights, advances and obstacles in the multi-faceted world of metabolomics.
For more information, please visit http://www.metabolomics2012.org.
|10 July 2012||
Merck Deep Dive: Translational Technologies
for Basic and Clinical Scientists
For more information, please visit http://www.cvent.com/events/merck-deep-dive-molecular-biomarkers-protemics-genomics-metabolomics-/event-summary-be463e01b8974ad99e3d84af4be50bef.aspx.
|28-31 Aug 2012||
NuGOweek 2012 (9th Edition): “Nutrition,
lifestyle and genes in the changing environment”
Venue & Accommodation
The conference venue and hotel is the hotel and conference centre Hilton Helsinki Kalastajatorppa .
Scientific & Conference Committee
The members of the Scientific Committee are:
Matti Uusitupa (chair), Jussi Pihlajamäki, Marjukka Kolehmainen, Kaisa Poutanen, Kirsti Husgafvel-Pursiainen, Jim Kaput, Martin Kussmann, Ben van Ommen, Lars Ove Dragsted, Stine Marie Ulven, Antonio Zorzano, Lorraine Brennan
The members of the Conference Organising Committee are:
Marjukka Kolehmainen, Matti Uusitupa, Kaisa Poutanen, Hannu Mykkänen, Jussi Pihlajamäki, Kati Hanhineva, Vanessa de Mello Laaksonen, Fré Pepping, Ingeborg van Leeuwen-Bol.
Further details about the programme will be made available end of February 2012.
Course on Metabolomics
Also this year we will organise a PhD course prior the NuGOweek. From 20-25 August 2012 the Course on Metabolomics 2012 will be held in Kuopio, Finland.
For further information please contact Ingeborg van Leeuwen-Bol.
For more information, please visit http://www.nugo.org/nugoweek/42113/5/0/30.
6) Metabolomics Jobs
This is a resource for advertising
positions in metabolomics. If you have a job you would like
posted in this newsletter, please email Ian Forsythe (email@example.com).
Job postings will be carried for a maximum of 4
issues (8 weeks) unless the position is filled prior to that
|Job Title||Employer||Location||Date Posted||Source|
position at INRA (France): Metabolomics for
identification of new biomarkers of dietary intake and
||UNH-INRA Centre de Recherche de Clermont-Ferrand/Theix||Saint-Genès-Champanelle, France
||UNH-INRA Centre de Recherche de Clermont-Ferrand/Theix|
position in Phytochemistry: Phytochemical investigation
of Medicinal Plants
||University of Pretoria||Pretoria, South Africa
||Metabolomics Society Jobs|
Director/Director – Metabolomics (Seeking an experienced
PhD Scientist to lead in-house metabolomics team that is
developing and applying state-of-the-art approaches to
investigate the intersection of cancer cell biology and
||Metabolomics Society Jobs|
Project DRIFT “Determination of Residues in Food
Scientist, PepsiCo R&D Long Term Research Biology
||700 Anderson Hill Road Purchase, New York 10577||27-Jan-2012
||Metabolomics Society Jobs|
|Postdoctoral Research Fellow in the Sumner lab focused on Metabolomics to Elucidate Genes of Unknown Function funded by NSF 2010 (PB-S095-570)||The Samuel Roberts Noble Foundation||Ardmore, OK 73401, USA||5-Jan-2012||Metabolomics Society Jobs|
|Postdoctoral Research Fellow in the Sumner lab focused on Computational Annotation of the Medicago and Arabidopsis Plant Metabolomes funded by a collaborative award from NSF & JST (PB-S095-700)||The Samuel Roberts Noble Foundation||Ardmore, OK 73401, USA||5-Jan-2012||Metabolomics Society Jobs|
|Postdoctoral Research Fellow in the Sumner lab focused on Empirical Annotation of the Medicago and Arabidopsis Plant Metabolomes funded by a collaborative award from NSF & JST (PB-S095-701)||The Samuel Roberts Noble Foundation||Ardmore, OK 73401, USA||5-Jan-2012||Metabolomics Society Jobs|
|Research Associate in the Analytical Chemistry Core Facility focused on GCMS Metabolomics Applications (PB-S070-125)||The Samuel Roberts Noble Foundation||Ardmore, OK 73401, USA||5-Jan-2012||Metabolomics Society Jobs|
|NMR Instrument Coordinator in the Sumner lab focused upon the successful installation and integration of a new NMR with UHPLC-MS and automated solid phase extraction (i.e., UHPLC-MS-SPE-NMR)||The Samuel Roberts Noble Foundation||Ardmore, OK 73401, USA||5-Jan-2012||Metabolomics Society Jobs|
|Postdoctoral Researcher in Molecular (Omics) Nanotoxicology||University of Birmingham||Birmingham, UK||4-Jan-2012||Metabolomics Society Jobs|
Ian J. Forsythe, M.Sc.MetaboNews
Department of Computing Science
University of Alberta
221 Athabasca Hall
Edmonton, AB, T6G 2E8, Canada
This newsletter is produced by The Metabolomics Innovation Centre (TMIC, http://www.metabolomicscentre.ca/) for the benefit of the worldwide metabolomics community.
A single source destination for fee-for-service metabolic profiling including comprehensive metabolite identification, quantification, and analysis