Issue 6 - January 2012
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1) Research Spotlight
2) Biomarker Beacon
3) Metabolomics Current Contents
|30 Jan 2012
Genetic regulation of metabolomic biomarkers – paths to cardiovascular diseases and type 2 diabetes - The research group at the Institute for Molecular Medicine Finland (FIMM) has revealed eleven new genetic regions associated with the blood levels of the metabolites, including new loci affecting well-established risk markers for cardiovascular disease and potential biomarkers for type 2 diabetes. The findings may help in elucidating the processes leading to common diseases. The study will be published in Nature Genetics.
In a study to the genetic variance of human metabolism, researchers have identified thirty one regions of the genome that were associated with levels of circulating metabolites, i.e., small molecules that take part in various chemical reactions of human body. Many of the studied metabolites are biomarkers for cardiovascular disease or related disorders, thus the loci uncovered may provide valuable insight into the biological processes leading to common diseases.
Laboratory tests used in the clinic typically monitor one or few circulating metabolites. The researchers at the Institute for Molecular Medicine Finland (FIMM) used a high throughput method called nuclear magnetic resonance (NMR) that can measure more than hundred different metabolites in one assay. This provides a much more in-depth picture of circulating metabolic compounds.
Paper: Kettunen J, Tukiainen T, Sarin A-P, Ortega-Alonso A, Tikkanen E, Lyytikäinen L-P, Kangas AJ, Soininen P, Würtz P, Silander K, Dick DM, Rose RJ, Savolainen MJ, Viikari J, Kähönen M, Lehtimäki T, Pietiläinen KH, Inouye M, McCarthy MI, Jula A, Eriksson J, Raitakari OT, Salomaa V, Kaprio J, Järvelin M-R, Peltonen L, Perola M, Freimer NB, Ala-Korpela M, Palotie A, Ripatti S. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nature Genetics, 29th January, 2012 (online).
|27 Jan 2012
Giant Cell Reveals Metabolic Secrets - Chemical reactions within the cell produce intermediate and end products in the form of small molecules called metabolites. Using an approach called metabolomics, a research team led by Kazuki Saito of the RIKEN Plant Science Center, Yokohama and Tsuruoka, has elucidated the localization and dynamics of 125 metabolites within a single giant cell of the freshwater alga Chara australis. The team's findings provide important insights into the fundamental processes of cells in general.
Metabolites play important roles in the regulation of critical biological processes, such as growth, differentiation, and, in the case of so-called 'secondary metabolites', chemical defense. "Metabolomics is the systematic study of these unique chemical footprints, and involves identifying and characterizing the many metabolites found in a cell, tissue, organ or organism, as well as their production, distribution and dynamics," explains Saito.
Because the enzymes involved in producing and converting different metabolites are often localized within subcellular structures called organelles, biologists generally assumed that metabolites are also highly compartmentalized within the cell, but none had demonstrated this comprehensively.
"Understanding the compartmentalization and dynamics of metabolites within single organelles represents an enormous technical challenge, not least because of the tiny size of these structures in most cells," says Saito.
Paper: Oikawa A, Matsuda F, Kikuyama M, Mimura T, Saito K. Metabolomics of a Single Vacuole Reveals Metabolic Dynamism in an Alga Chara australis. Plant Physiology, 2011; 157 (2): 544 DOI: 10.1104/pp.111.183772
|24 Jan 2012
Upregulated Metabolite May Be Target for Neuropathic Pain Therapy - Blocking overproduction of the metabolite N,N-dimethylsphingosine (DMS) in the spinal cord could feasibly represent a therapeutic option for treating neuropathic pain, researchers claim. A team at Washington University School of Medicine, St. Louis, and The Scripps Research Institute used an MS-based metabolomics approaches to compare metabolite levels in specific tissues of tibial nerve-transacted (TNT) experimental rats and sham-operated control rats. Tissues analyzed included spinal cord dorsal horn and dorsal root ganglia, damaged tibial nerve, and blood plasma.
Their results, reported in Nature Chemical Biology by Gary Siuzdak, Ph.D., and colleagues, demonstrated that 94% of metabolite differences between TNT rats and control rats occurred in the ipsilateral dorsal horn, rather than in the damaged nerve itself. When the team further characterized dysregulated metabolites in the dorsal horn tissue, they identified multiple alterations in sphingomyelin-ceramide metabolism 21 days after TNT injury. “We therefore hypothesized that dysregulated metabolites in this pathway may be linked to the physiological changes underlying neuropathic pain and represent possible new targets for therapeutic intervention,” they state.
The changes in dorsal horn metabolite concentrations were consistent with degradation of sphingomyelin, and included significant upregulation of DMS, which hasn’t previously been investigated in the context of neuropathic pain, the authors add. Of significant interest was the finding that intrathecal injections of DMS in healthy rats led to the animals developing mechanical allodynia (pain resulting from a stimulus that wouldn’t normally be painful) in the hind paw. This effect occurred at injected concentrations of DMS that resulted in similar dorsal horn levels of the metabolite that were found in the TNT experimental mice.
Paper: Patti GJ, Yanes O, Shriver LP, Courade JP, Tautenhahn R, Manchester M, Siuzdak G. Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin. Nat Chem Biol. 2012 Jan 22. doi: 10.1038/nchembio.767. [Epub ahead of print] [PMID: 22267119]
Source: Genetic Engineering & Biotechnology News
|3 Feb 2012||
Cancer Metabolomics: Elucidating the
Biochemical Programs that Support Cancer Initiation
Call for Poster Abstracts
A poster session will be held and a selected number of presenters will be asked to give brief oral presentations. The deadline for abstract submission is Friday, January 27, 2012. For abstract instructions, send an email to CancerMetabolomics@nyas.org with the words "Abstract Information" in the subject line. Instructions will be forwarded automatically. For questions, please call 212.298.8618.
For more information, please visit http://www.nyas.org/Events/Detail.aspx?cid=7fbbd804-93df-4a78-8127-8210ad9f3496.
|20-22 Feb 2012||
International Conference and Exhibition on
Metabolomics & Systems Biology
Metabolomics-2012 will serve as a catalyst for the advances in the study of Metabolomics & Systems Biology by connecting scientists within and across disciplines at sessions and exhibition held at the venue, creates an environment conducive to information exchange, generation of new ideas, and acceleration of applications that benefit Research in Metabolomics & Systems Biology.
Conference Highlights the following topics:
For more information, please visit http://omicsonline.org/metabolomics2012/.
|21-22 Feb 2012||
7th Annual Biomarkers Conference
The 7th Annual Biomarkers Congress 2012 presented by Oxford Global Conferences provides a first class educational and networking opportunity for over 250 attendees to gain knowledge and insights into the Biomarkers marketplace.
Do not miss out on the opportunity to learn how you can streamline your R&D process and identify potential cost savings through successful biomarker discovery, validation and clinical development.
Our CNS Biomarkers Congress 2012 which will be co-located with the 7th Annual Biomarkers Congress on the 21- 22 February will provide the opportunity for two days worth of deep analysis and insight into this growing CNS Biomarkers market.
For more information, visit http://www.biomarkers-congress.com/.
|12-14 Mar 2012||
Metabolic Leaders' Forum 2012
Phacilitate’s inaugural Metabolic Leaders’ Forum
takes a timely look at the decisions facing senior
R&D executives following the tightening up of
requirements for approving new drugs for adult-onset
diabetes coupled with the FDA’s more recent rejection
of three separate drugs to treat obesity. What are
your peers doing to establish appropriate CV benefits
profiles to demonstrate positive outcomes without
incurring exploding costs? How are companies large and
small rethinking and restructuring to optimize their
ability to compete in diabetes and obesity, and the
emerging cardiometabolic health field?
|17-20 Apr 2012||
analytica Conference 2012
In various symposiums, leading scientists from all over the world report on the latest developments, current trends and visions of the future. Analytic, diagnostic, biochemical and molecular biological methods and procedures are discussed here. On the last occasion, 140 well-known experts gave talks in 23 different thematic symposiums.
Main subject emphases/highlights of the analytica Conference 2010
For more information, please visit http://www.analytica.de/en/Home/congress/conference-program.
|7-8 May 2012||
LIPID MAPS Annual Meeting 2012: Lipidomics
Impact on Cell Biology, Metabolomics and
The meeting program tentatively features the following six sessions:
For more information, please visit http://www.lipidmaps.org/meetings/2012annual/
|20-24 May 2012||
60th ASMS Conference on Mass Spectrometry and
Jan 9, 2012: Conference registration and lodging opens online
Feb 3, 2012: Deadline for submission of abstracts
Apr 14, 2012: Conference program online
Apr 30, 2012: Deadline for advance registration
For more information, please visit http://www.asms.org/Conferences/AnnualConference/GeneralInformation/tabid/127/Default.aspx.
|21-23 May 2012||
Les 6èmes Journées
Scientifiques du Réseau Français de
Métabolomique et Fluxomique (JS 6 RFMF)
For more information, please visit https://colloque4.inra.fr/6_js_reseau_francais_metabolomique_fluxomique.
|25-28 June 2012||
METABOLOMICS 2012: Breakthroughs in plant,
microbial and human biology, clinical and
nutritional research, and biomarker discovery
The 2012 meeting promises a program full of practical workshops and parallel sessions covering the broad range of biological and technological metabolomics topics as well as providing rich opportunities for networking. Join us as we gather together to share ideas, insights, advances and obstacles in the multi-faceted world of metabolomics.
For more information, please visit http://www.metabolomics2012.org.
|10 July 2012||
Merck Deep Dive: Translational Technologies
for Basic and Clinical Scientists
For more information, please visit http://www.cvent.com/events/merck-deep-dive-molecular-biomarkers-protemics-genomics-metabolomics-/event-summary-be463e01b8974ad99e3d84af4be50bef.aspx.
6) Metabolomics Jobs
This is a resource for advertising
positions in metabolomics. If you have a job you would like
posted in this newsletter, please email Ian Forsythe (email@example.com).
Job postings will be carried for a maximum of 4
issues (8 weeks) unless the position is filled prior to that
|Job Title||Employer||Location||Date Posted||Source|
Scientist, PepsiCo R&D Long Term Research Biology
||700 Anderson Hill Road Purchase, New York 10577||27-Jan-2012
||Metabolomics Society Jobs|
in Metabolomics instrumental analysis
||IMDEA Food Institute
|Postdoctoral Research Fellow in the Sumner lab focused on Metabolomics to Elucidate Genes of Unknown Function funded by NSF 2010 (PB-S095-570)||The Samuel Roberts Noble Foundation||Ardmore, OK 73401, USA||5-Jan-2012||Metabolomics Society Jobs|
|Postdoctoral Research Fellow in the Sumner lab focused on Computational Annotation of the Medicago and Arabidopsis Plant Metabolomes funded by a collaborative award from NSF & JST (PB-S095-700)||The Samuel Roberts Noble Foundation||Ardmore, OK 73401, USA||5-Jan-2012||Metabolomics Society Jobs|
|Postdoctoral Research Fellow in the Sumner lab focused on Empirical Annotation of the Medicago and Arabidopsis Plant Metabolomes funded by a collaborative award from NSF & JST (PB-S095-701)||The Samuel Roberts Noble Foundation||Ardmore, OK 73401, USA||5-Jan-2012||Metabolomics Society Jobs|
|Research Associate in the Analytical Chemistry Core Facility focused on GCMS Metabolomics Applications (PB-S070-125)||The Samuel Roberts Noble Foundation||Ardmore, OK 73401, USA||5-Jan-2012||Metabolomics Society Jobs|
|NMR Instrument Coordinator in the Sumner lab focused upon the successful installation and integration of a new NMR with UHPLC-MS and automated solid phase extraction (i.e., UHPLC-MS-SPE-NMR)||The Samuel Roberts Noble Foundation||Ardmore, OK 73401, USA||5-Jan-2012||Metabolomics Society Jobs|
|Postdoctoral Researcher in Molecular (Omics) Nanotoxicology||University of Birmingham||Birmingham, UK||4-Jan-2012||Metabolomics Society Jobs|
|Metabolomics Tenured Faculty Position||UNC Chapel Hill||Kannapolis, North Carolina||4-Jan-2012||Scientific American Jobs|
|Postdoctoral researcher in environmental metabolomics||University of Birmingham||Birmingham, UK||15-Dec-2011
||Metabolomics Society Jobs|
|Post-doctoral position (18 months) - Cancer, Environment and Metabolomics||LABERCA
||Réseau Français de Métabolomique et Fluxomique|
Ian J. Forsythe, M.Sc.MetaboNews
Department of Computing Science
University of Alberta
221 Athabasca Hall
Edmonton, AB, T6G 2E8, Canada
This newsletter is produced by The Metabolomics Innovation Centre (TMIC, http://www.metabolomicscentre.ca/) for the benefit of the worldwide metabolomics community.
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