Issue 10 - May 2012
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1) Consortium Spotlight
Associate Professor, Molecular and Cellular Biology (College of Biological Sciences), UC Davis Genome Center (USA)
Member, Scientific Programs Committee, Metabolomics Society
Prof. Oliver Fiehn, PhD, has pioneered developments and applications in metabolomics since 1998 with over 130 publications to date. Dr. Fiehn is Full Professor at the UC Davis Genome Center, teaching biochemistry at the graduate and undergraduate level. He heads the Genome Center’s Metabolomics Facility, directing his research laboratory and overseeing the service core laboratory with a total of 9 mass spectrometers and 15 staff members.
Dr. Fiehn’s laboratory works at the interface of biology, informatics, and analytical chemistry. He is an outspoken advocate for metabolomic databases as a prerequisite for coherent and standardized reporting of metabolomic results. His laboratory develops mass spectral libraries as well as algorithms, databases, and public web-based tools. To date, almost 450 studies have been conducted covering more than 80 species detailed by over 35,000 samples. The laboratory hosts five metabolic platforms targeting: primary metabolism (<550 Da), lipidomics, volatiles, secondary metabolism, and metabolic polymers.
Dr. Fiehn is committed to serving the community by chairing efforts in establishing metabolomic standards within the Metabolomics Society for which he has served on the Board of Directors for over five years. Dr. Fiehn regularly reviews grant proposals for the NIH and serves as editor for the Rapid Communication in Mass Spectrometry, Metabolomics and Plant Methods.
3) Biomarker Beacon
4) Metabolomics Current Contents
|31 May 2012
ChromaDex®, Scripps Reach Deal to Generate Tandem Mass Spec Data for Metabolite Database
Natural products firm ChromaDex® and the Scripps Center for Metabolomics have formed a partnership to generate tandem mass spectrometry data for compounds for inclusion in a metabolite database
Data from compounds from ChromaDex's products and phytochemical catalog will be included in the Scripps Metlin Metabolite Database, which contains metabolite information, such as tandem mass spectrometry information, for more than 55,000 potentially therapeutic compounds.
Metlin, however, has only limited data on natural products, and including such information would enable researchers to screen potential compounds for use in areas of clinical interest, such as cancer, heart disease, diabetes, and Alzheimer's disease, ChromaDex® said.
The collaboration announced today "will further advance small molecule profiling to increase demand for natural product libraries through the ease of the Internet to assist in finding candidate compounds for research and development," ChromaDex® Founder and Chief Scientific Officer Frank Jaksch said in a statement.
ChromaDex® is based in Irvine, Calif., and provides solutions and ingredients to the dietary supplement, food and beverage, cosmetic, and pharmaceutical industries.
Gary Siuzdak, senior director for the Center for Metabolomics and Mass Spectrometry Scripps Research Institute, added that the inclusion of ChromaDex® compounds "will expand Metlin's compound library and mass spectrometry data to nutraceuticals and many novel plant-related natural products. The importance in the ChromaDex®/Metlin partnership is that it will facilitate metabolomics experiments around the world."
|24 May 2012
Metabolic Study Suggests Glycine Involved in Rapid Cancer Cell Growth - Quickly proliferating cancer cells are prone to an uptick in use of the amino acid glycine, a new Science study suggests.
Researchers from the US and Sweden came up with a mass spectrometry-based method called "consumption and release," or CORE, to profile metabolite use in cancer cells from the National Cancer Institute's human cancer cell line panel NCI-60 over time. To round out their metabolic analysis, they also folded in existing data on the expression of more than 1,400 metabolic enzyme-coding genes in the 60 primary cancer cell lines.
Across the lines, which represent nine cancer types, the team saw a surge in glycine consumption in fast-growing cells. In addition, quickly dividing cancer cells had higher-than-usual expression of genes that code for components of a glycine production pathway that operates in the cell's mitochondria.
On the other hand, cancer cells that were either grown in low glycine media or treated with short hairpin RNAs that silenced the mitochondrial glycine synthesis enzyme SHMT2 curbed the growth of quickly dividing cancer cells.
"We have two independent methods — metabolite profiling as well as gene expression profiling — both of which point to glycine metabolism as being important for rate of proliferation," corresponding author Vamsi Mootha, a systems biology researcher affiliated with the Broad Institute, Harvard Medical School, and Massachusetts General Hospital, said in a statement.
Mootha and his team used liquid chromatography and tandem mass spectrometry to track the flow of 219 metabolites moving into and out of cancer cells from the NCI-60 panel over four to five days.
"Using CORE, we can quantitatively determine exactly how much of every metabolite is being consumed or released on a per-cell, per-hour basis," co-first author Mohit Jain, a postdoctoral researcher in Mootha's lab, explained in a statement. "We can now start to derive flux or transport of nutrients into or out of the cell."
|14 May 2012
Genome Medicine Special Issue: Metabolomics of Disease - Rapid advances have been made in the prediction, detection, understanding and monitoring of human disease using metabolomic technologies. Genome Medicine presents a special issue devoted to metabolomics of disease, with specially commissioned comment and review articles, plus original research, to provide a state-of-the-art overview of this fast moving area and its clinical applications.
Several of the articles in this special issue are featured in the above Metabolomics Current Contents section.
Source: Genome Medicine
|18-21 June 2012||
Metabonomics Shortcourse 2012 - Metabolic
Phenotyping in Disease Diagnosis & Personalised
|25-28 June 2012||
METABOLOMICS 2012: Breakthroughs in plant,
microbial and human biology, clinical and
nutritional research, and biomarker discovery
The 2012 meeting promises a program full of practical workshops and parallel sessions covering the broad range of biological and technological metabolomics topics as well as providing rich opportunities for networking. Join us as we gather together to share ideas, insights, advances and obstacles in the multi-faceted world of metabolomics.
For more information, please visit http://www.metabolomics2012.org.
|10 July 2012||
Merck Deep Dive: Translational Technologies
for Basic and Clinical Scientists
For more information, please visit http://www.cvent.com/events/merck-deep-dive-molecular-biomarkers-protemics-genomics-metabolomics-/event-summary-be463e01b8974ad99e3d84af4be50bef.aspx.
|28-31 Aug 2012||
NuGOweek 2012 (9th Edition): “Nutrition,
lifestyle and genes in the changing environment”
Venue & Accommodation
The conference venue and hotel is the hotel and conference centre Hilton Helsinki Kalastajatorppa .
Scientific & Conference Committee
The members of the Scientific Committee are:
Matti Uusitupa (chair), Jussi Pihlajamäki, Marjukka Kolehmainen, Kaisa Poutanen, Kirsti Husgafvel-Pursiainen, Jim Kaput, Martin Kussmann, Ben van Ommen, Lars Ove Dragsted, Stine Marie Ulven, Antonio Zorzano, Lorraine Brennan
The members of the Conference Organising Committee are:
Marjukka Kolehmainen, Matti Uusitupa, Kaisa Poutanen, Hannu Mykkänen, Jussi Pihlajamäki, Kati Hanhineva, Vanessa de Mello Laaksonen, Fré Pepping, Ingeborg van Leeuwen-Bol.
Further details about the programme will be made available end of February 2012.
Course on Metabolomics
Also this year we will organise a PhD course prior the NuGOweek. From 20-25 August 2012 the Course on Metabolomics 2012 will be held in Kuopio, Finland.
For further information please contact Ingeborg van Leeuwen-Bol or visit http://www.nugo.org/nugoweek/42113/5/0/30.
|18-20 Sep 2012||
Metabolomics in Drug Discovery &
Metabolomics provide the ultimate answer to how genetic alterations, disease and environmental influences impact in vivo biology and drug action. That is why, increasingly, drug developers are embracing the benefits of using metabolomics to enhance all aspects of development, from lead discovery right through to post approval surveillance.
Uncovering new drug targets. Identifying safety & efficacy biomarkers. Using pharmaco-metabolomic data in clinical trial design.
Make sure you stay abreast of the last progress and start applying metabolomics to your pipeline.
Metabolomics in Drug Discovery & Development is the world’s only commercially focussed metabolomics meeting. Bringing together the industry leaders to debate what challenges still remain and what stages of drug development can benefit most.
What will you gain from attending?
For further information, please visit http://metabolomics-drugdevelopment.com/
|25-27 Sep 2012||
The conference centre is located within the University of Manchester campus, close to major transport links and one of the most cosmopolitan centres in the UK. The meeting is the seventh of the Metabomeeting conferences and continues the series of highly successful events held across Europe since 2005. The program will focus on the increasingly diverse range of applications as well as the latest developments to enhance the practise of metabolomics.
Confirmed speakers for the meeting include:
More details are available via http://thempf.org/mpf_cms/index.php/conferencesworkshops/forthcoming-mpf-events/78-metabomeeting-2012.
|16-17 Oct 2012||
Metabolic Profiling & Lipidomics
This conference aims to discuss the latest developments in the rapidly evolving area of metabolic profiling with particular emphasis on the break out field of Lipidomics. Recent HPLC-MS advances now allow for individual molecular species of lipids to be isolated and identified. This meeting will detail the cutting edge research taking place as a result of these developments with emphasis on understanding not only lipid metabolism but also ascertaining the role of lipids in conditions such as atherosclerosis, inflammatory disease, arthritis, cancer, diabetes and Alzheimer's disease, with a view to improving treatment. As a whole focus will be drawn to the key technological developments being made in both the separation and detection analytical fields used in profiling as well as the area’s other key applications including toxicity assessment, functional genomics and nutrigenomics.
Other conference tracks at this event include Cancer Proteomics, Exosomes/Markers in Biological Fluids, and Informatics. Registered delegates will have access to all four meetings ensuring a very cost-effective trip.
In addition the event will also host two cutting edge business courses which can be viewed here.
For further information, please visit http://selectbiosciences.com/conferences/index.aspx?conf=MPL2012
|7-9 Nov 2012||
29th LC/MS Montreux Symposium
The Montreux LC/MS 2012 conference: Special highlights on Metabolomics and Clinical Chemistry
The field of LC/MS is continuously growing as is reflected by the participation of over 30 nationalities and by scientific contributions from a variety of research and development domains such as pharmaceutical, biotechnological, food, environmental and research on novel instrumentation and new LC/MS fields such as nanotechnology and microfluidics, UPLC, low flow rate spray techniques, proteomics, and systems biology.
In collaboration with the Metabolomics Society, a special joint parallel program for this rapidly emerging field is organized addressing the technology as well as novel systems-based biology approaches in pharma, nutrition, clinical chemistry, plant sciences, and medical biology. A parallel program is organized together with various Clinical Chemistry societies focusing on current and future LC/MS options in clinical diagnosis. Accreditation by related societies for the program as well as the short course has been applied for.
For more information, visit http://www.lcms-montreux.com/.
Conference flyer (PDF): http://www.metabonews.ca/Mar2012/events/flyer_LC-MS _Montreux_conference_2012.pdf
7) Metabolomics Jobs
|Job Title||Employer||Location||Date Posted||Source|
|Postdoctoral Fellow in Mycobacterial Genetics and Systems||EMBL||Germany
|A researcher in
molecular plant science (m/f)
||Centre de Recherche Public - Gabriel Lippmann||Luxembourg||31-May-2012||Naturejobs.com|
||Janssen (Johnson & Johnson Group)||Toledo, Spain||31-May-2012||Naturejobs.com|
|PhD position in
|Metabolomics of fungal diseases: a systems biology approach for biomarkers discovery and therapy||Dipartimento di Medicina Sperimentale e Scienze Biochimiche||Italy||30-May-2012||Naturejobs.com|
|2 Research Fellowship to support PhD students for the project MAN-VIP||Fondazione Edmun Mach - Research and Innovation Centre||San Michele all'Adige (TN), Italy||30-May-2012||Naturejobs.com|
|Scientist||International Agency for Research on Cancer (IARC)||Lyon, France||25-May-2012||Naturejobs.com|
|Postdoctoral Researcher Microbiology, School of Natural Sciences||NUI Galway Ireland||Galway, Ireland||23-May-2012||Naturejobs.com|
|Lead Laboratory Scientist - Bioanalytics||Complex Matrix Characterization & Metabolomics Group, Switzerland High Res Mass Spec / Orbitrap (Paramount Recruitment)||Neuchâtel, Switzerland||21-May-2012||Naturejobs.com|
|Lead Lab Scientist - LCMS / GCMS||Complex Matrix Characterization & Metabolomics Group (Paramount Recruitment)||Neuchâtel, Switzerland||13-May-2012||Naturejobs.com|
|Analytical Chemist – Mass Spectrometry - Lead Lab Technician – Bioanalytics||Philip Morris International Products S.A.||Neuchâtel, Switzerland||8-May-2012||Naturejobs.com|
Chemist - Mass Spectrometry - Lead Lab Technician -
||Philip Morris International Products S.A.||Neuchâtel, Switzerland||8-May-2012||Naturejobs.com|
|Experimental Officer in Metabolomics||University of Birmingham||Birmingham, UK||16-Apr-2012||Metabolomics Society Jobs|
|Lectureship in Metabolomics / Metabolic Biochemistry||University of Birmingham||Birmingham, UK||16-Apr-2012||Metabolomics Society Jobs|
|Postdoc position in metabolomic NMR||University of Freiburg||Freiburg, Germany||12-Apr-2012||University
Ian J. Forsythe, M.Sc.MetaboNews
Department of Computing Science
University of Alberta
221 Athabasca Hall
Edmonton, AB, T6G 2E8, Canada
This newsletter is produced by The Metabolomics Innovation Centre (TMIC, http://www.metabolomicscentre.ca/) for the benefit of the worldwide metabolomics community.
A single source destination for fee-for-service metabolic profiling including comprehensive metabolite identification, quantification, and analysis