Issue 4 - November 2011
Welcome to the fourth issue of
MetaboNews, a monthly newsletter for the worldwide
metabolomics community. In this month's issue, we feature a Network Spotlight
article on Le Réseau Français de Métabolomique
et Fluxomique (French Metabolomic and Fluxomic Network). This
newsletter is being produced by The Metabolomics Innovation
Centre (TMIC, http://www.metabolomicscentre.ca/), and is
intended to keep metabolomics researchers and other
professionals informed about new technologies, software,
databases, events, job postings, conferences, training
opportunities, interviews, publications, awards, and other
newsworthy items concerning metabolomics. We hope to provide
enough useful content to keep you interested and informed and
appreciate your feedback on how we can make this newsletter
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Back issues of this newsletter can be viewed from the newsletter archive (http://www.metabonews.ca/archive.html).
1) Network Spotlight
In 2005, at a very competitive time in international metabolomics, the French metabolomics community was in a disorganized state. Out of a need to form a more structured metabolomics organization in France, the French Metabolomic and Fluxomic Network (RFMF, https://www.bordeaux.inra.fr/ifr103/reseau_metabolome/) was established in 2005. This newly formed organization aims to bring together all those in France who contribute to the development of Metabolomics and Fluxomics, and more broadly to the overall analysis of metabolism in France. The RFMF facilitates relationships between researchers, and ensures their representation in national and international organizations. It also serves as a centralized vantage point from which network leaders can observe the structure and evolution of metabolomics and fluxomics in France. During the last six years, the network has been involved in activities covering all aspects of metabolomics including scientific conferences, school research projects, training, advertising job opportunities, etc. The RFMF has also produced a directory and map listing various competencies in metabolomics and fluxomics by cities in France.
activities are part of a general framework of Integrative
Biology and cover four additional themes around the analysis
of metabolic systems:
The network consists of an independent, non-profit organization, governed by a board of eleven members, who are elected by secret ballot by the general assembly. Elections take place once every two years, and members may be reappointed. Elected members serve two-year terms, except the secretary, the scientific communication representative, and the treasurer; these individuals serve longer terms of five years and are elected by secret ballot by the board.
2) Biomarker Beacon
3) Metabolomics Current Contents
|23 Nov 2011
NMR Fine-Tuned for High-Content Metabolomics Screening - Scientists report on the development of a nuclear magnetic resonance (NMR)-based method for screening the metabolomic response of drug-treated mammalian cells to drug therapy. The Sanford-Burnham Medical Research Institute, and Rady Children’s Hospital investigators, say the highly sensitive, fast, and simple method is carried out in 96-well format, and could have particular utility as a method for high-throughput primary screens. The preparation technique takes just five minutes to metabolically inactivate and lyse hundreds of drug-treated samples, and a metabolomic screening of around 100 samples can be carried out in 24 hours.
Giovanni Paternostro, M.D., and colleagues describe their approach, analyze the results of validation studies on drug-treated cancer cell lines, and evaluate the technique for screening a kinase inhibitor library. Their work is described in Nature Communications in a paper titled “Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library.”
Paper: Tiziani S et al., Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library. Nat Commun. 2011 Nov 22;2:545. doi: 10.1038/ncomms1562. [PMID: 22109519]
|15 Nov 2011
Fat profile: breast cancer biomarkers laid bare - A multivariate statistical analysis of gas-chromatograph-mass spectrometry data has allowed one team to identify possible biomarkers for breast cancer simply from free fatty acid profiles. Such biomarkers might be useful in identifying breast cancer before patients show any symptoms and so allow interventions to be carried out well before any screening program would otherwise highlight a problem.
Breast cancer incidence is approximately 116 in every 100,000 women, according to Cancer Research UK. It comprises almost 23 percent of all cancers (excluding non-melanoma skin cancers) in women and accounts for around half a million deaths worldwide annually, around 14% of cancer deaths. Finding biomarkers for early prediction of the development of breast cancer is therefore a matter of urgency if those statistics are to be reduced.
Now, Wuwen Lv of Harbin University of Commence, and Tongshu Yang of The Affiliated Tumor Hospital of Harbin Medical University, Harbin Medical University, both in Harbin, People's Republic of China, have investigated the free fatty acid (FFA) metabolic profiles in order to identify putative biomarkers for distinguishing between breast cancer patients, those with benign problems and entirely healthy controls.
Paper: Lv W, Yang T. Identification of possible biomarkers for breast cancer from free fatty acid profiles determined by GC-MS and multivariate statistical analysis. Clin Biochem. 2011 Oct 26. [Epub ahead of print] [PMID: 22061338]
|11 Nov 2011
Metabolome mined for biofuels - Japanese and American scientists are teaming up to boost the production of biofuels with a host of studies that aim to increase understanding of the metabolome.
The metabolome is the group of chemical compounds produced in living cells that are used to generate energy, build structures and other life-sustaining biological processes.
The study of metabolites, known as metabolomics, is a piece to the puzzle of understanding how an organism works and behaves under particular circumstances in the same way that genomics brings understanding to the function of genes and proteomics to proteins.
"This is an incredibly important component of cellular function, or organism function, that will allow us to understand how everything fits together," Gregory Warr, a program director at the National Science Foundation, explained to me Thursday.
Currently, scientists can identify and characterize the properties of only a small fraction of the 10,000 to 15,000 metabolites that exist in any given plant. The hope is that increased understanding of these compounds will lead to needed breakthroughs in the production of biofuels.
"By understanding the metabolome, you can understand how one compound gets converted to another, to another, and then perhaps finally to something that's useful as a biofuel," said Warr, who is overseeing the U.S. arm of the Metabolomics for a Low Carbon Society.
The NSF together with the Japan Science and Technology Agency this week announced $12 million in funding for projects in this program.
International Conference and Exhibition on
Metabolomics & Systems Biology
Metabolomics-2012 will serve as a catalyst for the advances in the study of Metabolomics & Systems Biology by connecting scientists within and across disciplines at sessions and exhibition held at the venue, creates an environment conducive to information exchange, generation of new ideas, and acceleration of applications that benefit Research in Metabolomics & Systems Biology.
Conference Highlights the following topics:
For more information, please visit http://omicsonline.org/metabolomics2012/.
Second International Congress of
Translational Research in Human Nutrition:
Integrative approaches in nutrition research
Details to follow: http://thempf.org/mpf_cms/index.php/conferencesworkshops/other-forthcoming-events
analytica Conference 2012
In various symposiums, leading scientists from all over the world report on the latest developments, current trends and visions of the future. Analytic, diagnostic, biochemical and molecular biological methods and procedures are discussed here. On the last occasion, 140 well-known experts gave talks in 23 different thematic symposiums.
Main subject emphases/highlights of the analytica Conference 2010
For more information, please visit http://www.analytica.de/en/Home/congress/conference-program.
LIPID MAPS Annual Meeting 2012: Lipidomics
Impact on Cell Biology, Metabolomics and
The meeting program tentatively features the following six sessions:
For more information, please visit http://www.lipidmaps.org/meetings/2012annual/
Les 6èmes Journées
Scientifiques du Réseau Français de
Métabolomique et Fluxomique (JS 6 RFMF)
For more information, please visit https://www.bordeaux.inra.fr/ifr103/reseau_metabolome/document/meetings/courrier_preinscription_6JSRFMF_final.rtf
METABOLOMICS 2012: Breakthroughs in plant,
microbial and human biology, clinical and
nutritional research, and biomarker discovery
Local Organisers: Dan Bearden, Rick Beger, Rima Kaddurah-Daouk, Lloyd W. Sumner, Don Robertson, Padma Maruvada and Donna Kimball.
For more information, please visit http://www.metabolomics2012.org.
6) Metabolomics Jobs
This is a resource for advertising positions in metabolomics.
If you have a job you would like posted in this newsletter,
please email Ian Forsythe (email@example.com).
Job postings will be carried for a maximum of 4
issues (8 weeks) unless the position is filled prior to that
|Job Title||Employer||Location||Date Posted||Source|
|Stable Isotopes Scientist||Nestlé Research Center||Lausanne, Switzerland||1-Dec-2011
Français de Métabolomique et Fluxomique
Engineer position in Biostatistics
with skills in OMICS techniques
|L.C.H., the French horse doping control laboratory||Verrières le Buisson, France
||1-Dec-2011||Réseau Français de Métabolomique et Fluxomique|
||Metabolon||Raleigh-Durham, North Carolina Area
in Metabolomics and Computational Biology
|University of Birmingham, UK||Birmingham, UK||29-Nov-2011
||Metabolomics Society Jobs|
Metabolomics and Systems Biology - CVMED
||Pfizer Inc.||Cambridge, Massachusetts
research in molecular ecotoxicology/metabolomics
||University of Birmingham, UK||Birmingham, UK||11-Nov-2011||Metabolomics Society Jobs|
Department of Primary Industries
|Bundoora, Victoria, Australia
||Metabolomics Society Jobs|
||Department of Biochemistry,
University of Cambridge, UK
||Metabolomics Society Jobs|
Scientist (Ph.D.) – Molecular Physiology
|Algenol Biofuels||Bonita Springs, Florida
||Metabolomics Society Jobs|
||APOTEX INC.||Toronto, Ontario, Canada
Ian J. Forsythe, M.Sc.MetaboNews
Department of Computing Science
University of Alberta
221 Athabasca Hall
Edmonton, AB, T6G 2E8, Canada
This newsletter is produced by The Metabolomics Innovation Centre (TMIC, http://www.metabolomicscentre.ca/) for the benefit of the worldwide metabolomics community.