Issue 15 - November 2012
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1) Software Spotlight
Cluster Leader Metabolic Regulation within the Business Unit Bioscience at Plant Research International, Wageningen, Netherlands
Robert Hall was awarded a PhD in plant biotechnology and enzymology by the University of Edinburgh, UK. He has circa 28 years experience in research and (project) management, focusing mainly on crop plants. He is currently Cluster Leader Metabolic Regulation within the BU Bioscience at Plant Research International, Wageningen, The Netherlands and is also Managing Director of the Centre of Biosystems Genomics. He was Coordinator of the EU project META-PHOR which was focused on developing novel metabolomics technologies and bioinformatics strategies for plants. He was co-organizer of the International Metabolomics Congress, Amsterdam 2010 and is past President of the International Metabolomics Society. His primary research activities are centred on developing metabolomics technologies for applications in plants to benefit both science and industry.
3) Biomarker Beacon
4) Metabolomics Current Contents
|6 Nov 2012
Global metabolomic initiative announced
Investigators at Washington University and The Scripps Research Institute have announced the launch of a "Global Metabolomic Initiative" to facilitate meta-analyses on studies of the metabolism of bacteria, yeast, plants, animals and people.
The announcement of the Global Metabolomic Initiative was sent to more than 1,600 registered XCMS Online users who have uploaded a total of more than 35,000 files of metabolomic data to a web-based processing platform called XCMS Online.
XCMS Online is a public resource developed by Gary Siuzdak and colleagues at The Scripps Research Institute. Siuzdak, PhD, director of the Scripps Center for Metabolomics, is a pioneer in the systematic study of metabolites (metabolomics).
The goal of metabolomics is to take a urine, blood or tissue sample, analyze it with an instrument called a mass spectrometer, and acquire a complete profile of all of the small molecules in the sample. The profile might reveal whether the sample donor is ill, at risk of developing a disease, has been exposed to a toxin, or is unable to tolerate a drug therapy.
Gary J. Patti, assistant professor of chemistry, genetics and medicine at Washington University in St. Louis, who is co-leading the XCMS Online meta-study, predicts that many groundbreaking discoveries will emerge from these analyses.
"A lot of people suddenly are excited about metabolism again," Patti says. "People are seeing that metabolism provides a downstream signature of disease states which is complementary to that provided by genes and proteins. As a result, there has been a huge resurgence of interest in this area."
|5 Nov 2012
International Consortium Awarded €6M to Validate Pre-Eclampsia Early Detection Tests
The European Union has awarded 6 million euro of research funding under the FP7-health framework to a consortium which is working to bring a predictive test for pre-eclampsia to market. The consortium is coordinated by Prof Louise Kenny at University College Cork, Ireland and driven by two companies, Pronota NV of Belgium and Metabolomic Diagnostics Ltd. of Ireland, both at the forefront in the discovery and development of novel blood-borne biomarkers for disease prediction.
The IMPROvED (IMproved PRegnancy Outcomes via Early Detection) project will establish a multicentre clinical study to assess and refine two innovative prototype screening tests for this common late pregnancy complication. These tests are based on proteomic and metabolomic profiles developed by the two companies.
Prof Louise Kenny, co-ordinating principal investigator of IMPROvED commented: "Pre-eclampsia is a very serious condition. It affects almost one in 20 first time mothers and globally causes approximately 70,000 maternal deaths each year. We were therefore extremely pleased to see that researchers from different fields, centres and countries were enthusiastic about the IMPROvED project. Our ultimate goal is to develop a robust predictive test for pre-eclampsia and to improve the outcome of pregnancy for both mothers and their babies."
Katleen Verleysen, CEO of Pronota says: "A predictive test for pre-eclampsia, and in particular for preterm pre-eclampsia, will significantly improve maternal and fetal health. We are excited to be part of the consortium. The IMPROvED clinical trial will allow Pronota to progress its proteomics based risk stratification test."
Charles Garvey, CEO of Metabolomics Diagnostics added: "Metabolomic Diagnostics, is delighted to be involved in this innovative consortium. We believe that an early pregnancy-screening test can make a major contribution to maternal safety and this project, once completed, will help accelerate its adoption."
The four-year IMPROvED project will establish a high quality pregnancy biobank with blood samples collected from 5,000 first-time pregnant women recruited from at least five countries including Ireland, the United Kingdom, Germany, Sweden and the Netherlands. All recruitment centres involved (University College Cork, Erasmus University Rotterdam, Klinikum der Universität zu Köln, The University of Liverpool, Karolinska Institute, University of Keele) are major obstetric centres with a proven track record in the research and management of pre-eclampsia. The scientific value of the biobank will be enhanced by the collection and storage of comprehensive clinical data along with the samples (Medscinet AB, Sweden). Dedicated and independent teams of statisticians (Region Hovedstaden, Denmark) and economics (University of Groningen) will ascertain clinical and health economical validity of the developed proteomics and metabolomics tests.
Prof Phil Baker (Keele University), co-principal investigator, added: "An effective screening test will allow antenatal care to be tailored to an individual woman's risk, such that at risk women receive the best possible care – so diminishing the burden of this potentially devastating disease. The approval of IMPROvED is a strong endorsement of European researchers and is recognising the importance of enhancing maternal and fetal health."
|31 Oct 2012
Agilent Technologies and Spain's Centre for Omic Sciences to Collaborate on Integrated Systems Biology Research
Agilent Technologies, Inc., and Spain's Centre for Omic Sciences announced that they will collaborate on mass spectrometry and NMR-based metabolomics, and automation applied to research in integrated systems biology.
The Centre for Omic Sciences, or COS, was established by the Rovira i Virgili University, in collaboration with the Technological Centre of Nutrition and Health. COS opened in September and is equipped with the latest instrumentation from Agilent, including the 6550 iFunnel Quadrupole Time-of-Flight LC/MS, 7200 Quadrupole Time-of-Flight GC/MS, 6490 iFunnel Triple Quadrupole LC/MS, Bravo automated liquid handling systems, and the SureScan DNA microarray scanner, software, consumables and services.
"Agilent is an ideal partner because many of their workflow solutions are an excellent fit for our approach to integrating data from different omics techniques," said Oscar Yanes, principal investigator at the COS. "The ability to generate data using mostly Agilent instrumentation will facilitate the interpretation and integration of results from the different techniques." The COS will also serve as a center of excellence where Agilent will demonstrate integrated biology workflows to customers in such disciplines as genomics, proteomics, transcriptomics, lipidomics and metabolomics in search of biological breakthroughs.
"This is a very strategic association between two organizations with similar goals," said Gustavo Salem, Agilent vice president and general manager, Biological Systems Division. "Both are committed to driving advances in medicine by developing better ways to integrate data from multiple biological disciplines. We share this vision."
The COS will perform its collaborative research programs and services with the Technological Centre of Nutrition and Health and with private companies and research groups that take a special interest in the fields of diabetes and metabolic diseases, nutrition and health, and other biomedical research areas.
|7-9 Nov 2012||
29th LC/MS Montreux Symposium
The Montreux LC/MS 2012 conference: Special highlights on Metabolomics and Clinical Chemistry
The field of LC/MS is continuously growing as is reflected by the participation of over 30 nationalities and by scientific contributions from a variety of research and development domains such as pharmaceutical, biotechnological, food, environmental and research on novel instrumentation and new LC/MS fields such as nanotechnology and microfluidics, UPLC, low flow rate spray techniques, proteomics, and systems biology.
In collaboration with the Metabolomics Society, a special joint parallel program for this rapidly emerging field is organized addressing the technology as well as novel systems-based biology approaches in pharma, nutrition, clinical chemistry, plant sciences, and medical biology. A parallel program is organized together with various Clinical Chemistry societies focusing on current and future LC/MS options in clinical diagnosis. Accreditation by related societies for the program as well as the short course has been applied for.
|9-11 Nov 2012||
Workshop on Holistic Analytical Technologies
for BioMedical, Food and Plant Sciences
Keynote speakers will comprise renowned scientists from academia and industry who will describe the remarkable advancement of analytical technologies (LC-MS, GC-MS, NMR) and data mining tools used for metabolomics research.
Preliminary list of Keynote speakers:
Dr. Toby J. Athersuch (Imperial College London)
Prof. Soren B Engelsen (University of Copenhagen)
Prof. Elaine Holmes (Imperial College London)
Prof. Ian Wilson (AstraZeneca UK)
Prof. Robert Verpoorte (Leiden University)
Dr. John Shockor (Waters)
Prof. Hermann Stuppner (University of Innsbruck)
Dr. Maria Klapa (FORTH)
Dr. Liz Want (Imperial College London)
Prof. Jean-Luc Wolfender (University of Geneva)
A poster session will provide the means for on-site open discussion to exchange ideas, and experiences. The workshop should provide an excellent learning opportunity, as well as a venue for the exchange of ideas among a highly interdisciplinary group of scientists. A special issue of Journal of Chromatography B will cover the works of the meeting.
For more information, visit the workshop website.
|12-13 Nov 2012||
Duke University Department of Medicine
A second partnership hires candidate for the metabolic flux position is Jurre Kamphorst, PhD, from the Lewis-Sigler Institute of Integrated Genomics at Princeton. Dr. Kamphorst has been training there in the lab of Josh Rabinowitz, who leads one of the very best metabolomics groups in the country. Dr. Kamphorst will give a lecture entitled "Metabolomic analysis of human pancreatic tumors reveals scavenging of albumin and lysolipids: opportunities for novel therapeutic strategies."
Tues., Nov. 13 at 5:00 p.m. in the Stedman Auditorium (Center for Living campus)
Finally, our regular Stedman Metabolism Forum lecture will be given by Darryl Quarles, MD, director of nephrology and associate dean for research at the University of Tennessee Health Sciences Center. His talk is entitled "Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks." Dr. Quarles is an expert in vitamin D metabolism, and also studies the relationship between bone-derived factors and metabolic regulation and kidney function. He is of a long-time "Dukie" so please join us in welcoming Daryl back to campus.
For more information, visit http://news.medicine.duke.edu/2012/11/newgard-invites-all-to-four-metabolomics-talks-in-november/
|3-6 Dec 2012||
Metabonomics Shortcourse 2012 - Metabolic
Phenotyping in Disease Diagnosis & Personalised
For more information, please contact:
|27 Jan-1 Feb 2013||
Gordon Research Conference on Plant Lipids:
Structure, Metabolism & Function
For the first time, a pre-conference Gordon Research Seminar (GRS) , January 26-27, 2013 at the same location, is being organized by investigators at the graduate student and postdoctoral levels for investigators at the graduate student and postdoctoral levels. This seminar is intended to provide (1) background that will enhance understanding of science presented at the subsequent conference, (2) opportunities to share research and to network with peers and experts in the field, and (3) peer and expert feedback and supportive suggestions about ongoing research.
For more information, visit http://www.metabolomicssociety.org/scientific_events and http://www.grc.org/programs.aspx?year=2013&program=plantlipid
|8-10 Apr 2013||
2nd International Conference and Exhibition
on Metabolomics & Systems Biology
Metabolomics-2013 is a remarkable event which brings together a unique and International mix of large and medium pharmaceutical, biotech and diagnostics companies, leading universities and clinical research institutions making the conference a perfect platform to share experience, foster collaborations across industry and academia, and evaluate emerging technologies across the globe.
2nd International Conference and Exhibition on Metabolomics & Systems Biology will serve as a catalyst for the advances in the study of Metabolomics & Systems Biology by connecting scientists within and across disciplines at sessions and exhibition held at the venue, creates an environment conducive to information exchange, generation of new ideas, and acceleration of applications that benefit research in Metabolomics & Systems Biology.
For more information, visit http://omicsgroup.com/conferences/metabolomics-systems-biology-2013/.
|1-4 Jul 2013||
9th Annual International Meeting of the
We expect this to be the 'must attend' meeting in 2013 for researchers from around the world, where the best speakers in the world and rising stars of the future will present their work in a mixture of plenary and parallel sessions. The Metabolomics Society came into being with the development of the Metabolomics as a discipline and as a result provides a focus for the most varied aspects of the subject ranging from microbes to man. As a result of this it brings together a diverse mixture of scientists from many disciplines, which produces very stimulating meetings.
One of the main aims of the conference will be to create a unique platform for young scientists. Come and listen and talk to the top experts in the field. Find out about the latest exciting technologies that can advance your own research, but most of all come and enjoy Scotland's largest and most vibrant city and the beautiful countryside around it.
We look forward to welcoming you to Glasgow in 2013!
Chair, Local Organising Committee
Metabolomics Glasgow 2013
For more information, visit http://www.metabolomics2013.org/.
7) Metabolomics Jobs
This is a resource for advertising
positions in metabolomics. If you have a job you would like
posted in this newsletter, please email Ian Forsythe (firstname.lastname@example.org).
Job postings will be carried for a maximum of 4
issues (8 weeks) unless the position is filled prior to that
|Job Title||Employer||Location||Date Posted||Source|
of Laboratory Operations
||Durham, NC, USA||29-Oct-2012||Metabolomics
positions in Advanced Metabolomics
||NIH West Coast Metabolomics Center, UC Davis||Davis, CA, USA
Position in Metabolomics
||Georgetown University||Washington, DC, USA
Inflammation and Malnutrition Using Metabolomics - Open
||The Pennsylvania State University||University Park, PA, USA
Professor of Biology
||University of Virginia
||Charlottesville, VA, USA
Professor – Professor (Director of Metabolomics)
||Beaumont Health System and the Beaumont Research Institute||Royal Oak, MI, USA||21-Sep-2012||Beaumont
Research Project in Bioanalysis/ Metabolomics
||Metabolomic Discoveries GmbH||Potsdam, Germany||20-Sep-2012||BioTOP
There are no postings at this time.
Ian J. Forsythe, M.Sc.MetaboNews
Department of Computing Science
University of Alberta
221 Athabasca Hall
Edmonton, AB, T6G 2E8, Canada
This newsletter is produced by The Metabolomics Innovation Centre (TMIC, http://www.metabolomicscentre.ca/) for the benefit of the worldwide metabolomics community.
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